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59 Prospective studies on this topic have focused mainly on normalising serum B 12 concentrations and should be interpreted with caution since the specific goal of treatment in symptomatic B 12 deficiency is alleviating symptoms

Fingolimod, a sphingosine-1-phosphate receptor 1 modulator, regulates the immune response to UC by suppressing the AKT/mTOR pathway, thereby regulating the balance of proinflammatory cytokines and anti-inflammatory cytokines

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Therefore, the TRPV1 is activated in rat DRG neuron by depletion of intracellular GSH (Naziroglu et al., 2013), although hyperalgesia and the TRPV1 channel were inhibited in the DRG neurons of rats by treatment of thiol redox cycle members such as GSH, selenium and NAC (Khodorova et al., 2013